Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.8
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.1
Supplement Facts
Serving Size: 1 Capsule
Amount Per Serving
%DV
Iron (from Ionic Plant Based Minerals)
2 mg
10%
HSO Probiotic Blend (5 Billion CFU)¹Saccharomyces boulardii, Organic Barley Grass², Organic Oat Grass², Lactobacillus plantarum, Bacillus subtilis, Bifidobacterium lactis, Bifidobacterium bifidum, Lactobacillus rhamnosus, Bifidobacterium breve, Lactobacillus casei, Lactobacillus salivarius, Lactobacillus acidophilus, Lactobacillus brevis, Bifidobacterium longum, Lactobacillus paracasei
410 mg
+
Ionic Plant Based Minerals
290 mg
+
Top Medical Research Studies
9.5
We explored how Saccharomyces boulardii might help prevent liver damage caused by Salmonella Enteritidis, a common foodborne pathogen. Using a mouse model, we noticed that pretreatment with S. boulardii significantly reduced the translocation of Salmonella to the liver by 96%.
Additionally, this treatment decreased inflammation and lesions associated with liver injury. These findings suggest that S. boulardii can be a powerful ally in protecting our livers against food poisoning caused by Salmonella Enteritidis.
Additionally, this treatment decreased inflammation and lesions associated with liver injury. These findings suggest that S. boulardii can be a powerful ally in protecting our livers against food poisoning caused by Salmonella Enteritidis.
Read More
9
Lacticaseibacillus rhamnosus shows promise
We explored the potential of Lacticaseibacillus rhamnosus GG as a probiotic treatment against avian pathogenic E. coli (APEC) in chickens. Our study showed that this probiotic significantly reduced APEC colonization in the chickens' cecum and improved the balance of gut microbiota over a 24-hour period.
Through laboratory evaluations, we detected novel bioactive peptides in the probiotic's culture supernatants, which may contribute to its antibacterial properties. While the results are promising for poultry health, more research is needed to optimize its use in real farming conditions.
Through laboratory evaluations, we detected novel bioactive peptides in the probiotic's culture supernatants, which may contribute to its antibacterial properties. While the results are promising for poultry health, more research is needed to optimize its use in real farming conditions.
Read More
9
We aimed to find out if probiotic supplements like lactobacillus acidophilus could help counteract the negative effects of iron fortification, which has been linked to increased diarrhea and food poisoning among children.
In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.
However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.
This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.
In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.
However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.
This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.
Read More
Most Useful Reviews
0
Mixed efficacy
53 people found this helpful
I experienced food poisoning-like symptoms when trying different probiotics. Although Jarro-Dophilus EPS helped initially, I didn't notice any effect from Garden of Life's Primal Defense. In a comparison, it didn’t provide the same relief, and I felt as if I was taking a placebo.
Read More
0
Adverse reaction
28 people found this helpful
DO NOT TAKE! After just two doses, I experienced severe symptoms akin to food poisoning. It felt toxic, and I barely recovered. I cannot recommend this product.
Read More
0
Minimal effect
18 people found this helpful
I have a significant candida issue and tried this probiotic at the maximum dosage, but it did little to alleviate my symptoms. I found better results with a cheaper alternative, and I wouldn't expect much from this product for severe issues.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 9 Researches
8.8
- All Researches
9.5
We explored how Saccharomyces boulardii might help prevent liver damage caused by Salmonella Enteritidis, a common foodborne pathogen. Using a mouse model, we noticed that pretreatment with S. boulardii significantly reduced the translocation of Salmonella to the liver by 96%.
Additionally, this treatment decreased inflammation and lesions associated with liver injury. These findings suggest that S. boulardii can be a powerful ally in protecting our livers against food poisoning caused by Salmonella Enteritidis.
Additionally, this treatment decreased inflammation and lesions associated with liver injury. These findings suggest that S. boulardii can be a powerful ally in protecting our livers against food poisoning caused by Salmonella Enteritidis.
Read More
9
We aimed to find out if probiotic supplements like lactobacillus acidophilus could help counteract the negative effects of iron fortification, which has been linked to increased diarrhea and food poisoning among children.
In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.
However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.
This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.
In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.
However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.
This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.
Read More
9
Probiotics reduce Salmonella colonization
We looked at how an avian-specific probiotic could help reduce food poisoning risks linked to Salmonella Enteritidis in poultry. Our study used chicks that received a special probiotic treatment and compared them to a control group.
The results showed a marked decrease in Salmonella Enteritidis colonization in the treated chicks over several days, especially at days 3, 7, and beyond. However, body weight gains appeared similar between both groups.
Overall, our findings suggest that using Lactobacillus acidophilus as part of the treatment may effectively lower Salmonella risks in broilers.
The results showed a marked decrease in Salmonella Enteritidis colonization in the treated chicks over several days, especially at days 3, 7, and beyond. However, body weight gains appeared similar between both groups.
Overall, our findings suggest that using Lactobacillus acidophilus as part of the treatment may effectively lower Salmonella risks in broilers.
Read More
9
Lacticaseibacillus rhamnosus shows promise
We explored the potential of Lacticaseibacillus rhamnosus GG as a probiotic treatment against avian pathogenic E. coli (APEC) in chickens. Our study showed that this probiotic significantly reduced APEC colonization in the chickens' cecum and improved the balance of gut microbiota over a 24-hour period.
Through laboratory evaluations, we detected novel bioactive peptides in the probiotic's culture supernatants, which may contribute to its antibacterial properties. While the results are promising for poultry health, more research is needed to optimize its use in real farming conditions.
Through laboratory evaluations, we detected novel bioactive peptides in the probiotic's culture supernatants, which may contribute to its antibacterial properties. While the results are promising for poultry health, more research is needed to optimize its use in real farming conditions.
Read More
9
We explored the effectiveness of a synbiotic treatment combining Bifidobacterium longum and xylo-oligosaccharides in fighting Campylobacter jejuni, a major cause of food poisoning. The treatment was administered either from day one or day fourteen of the chicks' lives.
Our findings showed that early supplementation led to a significant reduction in C. jejuni levels compared to later treatment. However, Bifidobacterium levels did not significantly differ among treatment groups. These results suggest that early synbiotic use alongside other safety measures could help improve poultry meat safety.
Our findings showed that early supplementation led to a significant reduction in C. jejuni levels compared to later treatment. However, Bifidobacterium levels did not significantly differ among treatment groups. These results suggest that early synbiotic use alongside other safety measures could help improve poultry meat safety.
Read More
User Reviews
USERS' SCORE
Medium or Average
Based on 6 Reviews
6.1
- All Reviews
- Positive Reviews
- Negative Reviews
0
Mixed efficacy
53 people found this helpful
I experienced food poisoning-like symptoms when trying different probiotics. Although Jarro-Dophilus EPS helped initially, I didn't notice any effect from Garden of Life's Primal Defense. In a comparison, it didn’t provide the same relief, and I felt as if I was taking a placebo.
Read More
0
Adverse reaction
28 people found this helpful
DO NOT TAKE! After just two doses, I experienced severe symptoms akin to food poisoning. It felt toxic, and I barely recovered. I cannot recommend this product.
Read More
0
Minimal effect
18 people found this helpful
I have a significant candida issue and tried this probiotic at the maximum dosage, but it did little to alleviate my symptoms. I found better results with a cheaper alternative, and I wouldn't expect much from this product for severe issues.
Read More
9
Life-saving probiotic
8 people found this helpful
THIS PROBIOTIC SAVED MY LIFE. As someone with IBS-D, I often felt confined to my bathroom. After years of suffering and various treatments, I discovered Primal Defense in a health food shop. Unlike previous probiotics that needed refrigeration, this one was different. I've felt amazing since using it for the past four years until I temporarily ran out. While another product was insufficient, I realised I depend on Primal Defense to avoid the return of my discomfort.
Read More
9
Effective after radiation
6 people found this helpful
This is the best probiotic I've found. It really helped after I lost a significant amount of microflora due to radiation therapy, causing severe pain and food poisoning-like symptoms.
Read More
Frequently Asked Questions
0
Adverse reaction
28 people found this helpful
DO NOT TAKE! After just two doses, I experienced severe symptoms akin to food poisoning. It felt toxic, and I barely recovered. I cannot recommend this product.
9
Life-saving probiotic
8 people found this helpful
THIS PROBIOTIC SAVED MY LIFE. As someone with IBS-D, I often felt confined to my bathroom. After years of suffering and various treatments, I discovered Primal Defense in a health food shop. Unlike previous probiotics that needed refrigeration, this one was different. I've felt amazing since using it for the past four years until I temporarily ran out. While another product was insufficient, I realised I depend on Primal Defense to avoid the return of my discomfort.
9
Effective after radiation
6 people found this helpful
This is the best probiotic I've found. It really helped after I lost a significant amount of microflora due to radiation therapy, causing severe pain and food poisoning-like symptoms.
9
UC remission support
4 people found this helpful
This has helped my husband with his Ulcerative Colitis. After taking it for over a year, he remained in remission for five years. We returned to it during a recent flare-up, and it has worked wonders to manage his symptoms.
0
Minimal effect
18 people found this helpful
I have a significant candida issue and tried this probiotic at the maximum dosage, but it did little to alleviate my symptoms. I found better results with a cheaper alternative, and I wouldn't expect much from this product for severe issues.
0
Mixed efficacy
53 people found this helpful
I experienced food poisoning-like symptoms when trying different probiotics. Although Jarro-Dophilus EPS helped initially, I didn't notice any effect from Garden of Life's Primal Defense. In a comparison, it didn’t provide the same relief, and I felt as if I was taking a placebo.
9
We aimed to find out if probiotic supplements like lactobacillus acidophilus could help counteract the negative effects of iron fortification, which has been linked to increased diarrhea and food poisoning among children.
In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.
However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.
This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.
In our study with weaning mice, we discovered that high iron diets led to more severe symptoms when infected with Salmonella.
However, when we added lactobacillus acidophilus beforehand, the mice showed less severe symptoms and better intestinal health.
This suggests that probiotics can really help protect gut health against the adverse effects of iron supplements during foodborne infections.
7
We explored whether Lactobacillus acidophilus, in both live and heat-killed forms, could protect against Salmonella-induced food poisoning. For two weeks, Sprague-Dawley rats received oral doses of L. acidophilus before being exposed to Salmonella.
The rats treated with heat-killed bacteria showed only a moderate rise in body temperature and maintained normal feeding and drinking habits. Although the number of Salmonella in feces was similar in both groups, heat-killed L. acidophilus significantly reduced inflammatory markers compared to the control group.
While it appears L. acidophilus may aid in managing Salmonella infections, it’s important to note that its overall impact may be limited.
The rats treated with heat-killed bacteria showed only a moderate rise in body temperature and maintained normal feeding and drinking habits. Although the number of Salmonella in feces was similar in both groups, heat-killed L. acidophilus significantly reduced inflammatory markers compared to the control group.
While it appears L. acidophilus may aid in managing Salmonella infections, it’s important to note that its overall impact may be limited.
9.5
We explored how Saccharomyces boulardii might help prevent liver damage caused by Salmonella Enteritidis, a common foodborne pathogen. Using a mouse model, we noticed that pretreatment with S. boulardii significantly reduced the translocation of Salmonella to the liver by 96%.
Additionally, this treatment decreased inflammation and lesions associated with liver injury. These findings suggest that S. boulardii can be a powerful ally in protecting our livers against food poisoning caused by Salmonella Enteritidis.
Additionally, this treatment decreased inflammation and lesions associated with liver injury. These findings suggest that S. boulardii can be a powerful ally in protecting our livers against food poisoning caused by Salmonella Enteritidis.
References
- Lin F, Wu H, Zeng M, Yu G, Dong S, et al. Probiotic/prebiotic correction for adverse effects of iron fortification on intestinal resistance to Salmonella infection in weaning mice. Food Funct. 2018;9:1070. doi:10.1039/c7fo00990a
- Kim MS, Yoon YS, Seo JG, Lee HG, Chung MJ, et al. A study on the prevention of salmonella infection by using the aggregation characteristics of lactic Acid bacteria. Toxicol Res. 2013;29:129. doi:10.5487/TR.2013.29.2.129
- Tellez G, Petrone VM, Escorcia M, Morishita TY, Cobb CW, et al. Evaluation of avian-specific probiotic and Salmonella enteritidis-, Salmonella typhimurium-, and Salmonella heidelberg-specific antibodies on cecal colonization and organ invasion of Salmonella enteritidis in broilers. J Food Prot. 2001;64:287.
- Kathayat D, Closs G, Helmy YA, Deblais L, Srivastava V, et al. In Vitro and In Vivo Evaluation of Lacticaseibacillus rhamnosus GG and Bifidobacterium lactis Bb12 Against Avian Pathogenic Escherichia coli and Identification of Novel Probiotic-Derived Bioactive Peptides. Probiotics Antimicrob Proteins. 2022;14:1012. doi:10.1007/s12602-021-09840-1
- Baffoni L, Gaggìa F, Garofolo G, Di Serafino G, Buglione E, et al. Evidence of Campylobacter jejuni reduction in broilers with early synbiotic administration. Int J Food Microbiol. 2017;251:41. doi:10.1016/j.ijfoodmicro.2017.04.001
- Baffoni L, Gaggìa F, Di Gioia D, Santini C, Mogna L, et al. A Bifidobacterium-based synbiotic product to reduce the transmission of C. jejuni along the poultry food chain. Int J Food Microbiol. 2012;157:156. doi:10.1016/j.ijfoodmicro.2012.04.024
- Santini C, Baffoni L, Gaggia F, Granata M, Gasbarri R, et al. Characterization of probiotic strains: an application as feed additives in poultry against Campylobacter jejuni. Int J Food Microbiol. 2010;141 Suppl 1:S98. doi:10.1016/j.ijfoodmicro.2010.03.039
- Allahyari S, Pakbin B, Dibazar SP, Karami N, Hamidian G, et al. Probiotic Saccharomyces boulardii Against Cronobacter sakazakii Infection: In Vitro and In Vivo Studies. Probiotics Antimicrob Proteins. 2025. doi:10.1007/s12602-025-10524-3
- Wu D, Teng D, Wang X, Dai C, Wang J. Saccharomyces boulardii prevention of the hepatic injury induced by Salmonella Enteritidis infection. Can J Microbiol. 2014;60:681. doi:10.1139/cjm-2014-0259
